产品名称
MIF (12G11) Rabbit Monoclonal Antibody
别名
GIF; GLIF; Glycosylation inhibiting factor; L-dopachrome isomerase; MIF protein; MMIF;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P14174
免疫原
Recombinant protein of human MIF
稀释度
WB: 1:1000 ICC/IF: 1:20 FC: 1:100
注意事项
MIF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens
功能
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
