RM5207

CD40L (15O10) Rabbit Monoclonal Antibody

CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; CD154; CD40 ligand, membrane form; CD40 ligand, soluble form; CD40LG; CD40L; TNFSF5; TRAP;

Affinity-chromatography

常规抗体

CD40LG

CD40L, TNFSF5, TRAP

WB

Human,Mouse

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

959

P29965

WB 1:500~1:2000

29kDa

Rabbit IgG

CD40L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Specifically expressed on activated CD4+ T- lymphocytes

Cell membrane; Single-pass type II membrane protein. Cell surface

Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).

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