产品名称
NMDAR1 (5R10) Rabbit Monoclonal Antibody
别名
GluN1; NMD-R1; GRIN1; NMDAR1
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q05586
免疫原
A synthetic peptide of human NMDAR1
稀释度
WB: 1:2000 ICC/IF: 1:50
注意事项
NMDAR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities.
功能
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:
7685113, PubMed:
28126851, PubMed:
26919761, PubMed:
26875626, PubMed:
28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:
26919761).
