RM5179

NFAT1 (11H19) Rabbit Monoclonal Antibody

cytoplasmic 2; NF ATp; NF-ATc2; NF-ATp; NFAT 1; NFAT1; NFAT1-D; NFATc2; NFATp;

Affinity-chromatography

常规抗体

NFATC2

NFAT1, NFATP

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

4773

Q13469

WB 1:500~1:2000

100kDa

Rabbit IgG

NFAT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid.

Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.

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