产品名称
Noxa (18H19) Rabbit Monoclonal Antibody
别名
APR; ATL-derived; NOXA; Pmaip1; Protein Noxa;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q13794
免疫原
A synthetic peptide of human Noxa
注意事项
Noxa Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in adult T-cell leukemia cell line
功能
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
