产品名称
VAMP2 (3Z10) Rabbit Monoclonal Antibody
别名
RATVAMPB; RATVAMPIR; SYB2; Synaptobrevin 2; Vamp2l; Vesicle-associated membrane protein 2 (synaptobrevin 2);
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P63027
免疫原
A synthetic peptide of human VAMP2
稀释度
WB: 1:2000-1:10000 ICC/IF: 1:50 FC: 1:20 IP: 1:20
注意事项
VAMP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Nervous system and skeletal muscle.
细胞定位
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell membrane {ECO:0000250|UniProtKB:P63045}. Note=Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651)
功能
Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:
30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
