产品名称
Rhodopsin (15I9) Rabbit Monoclonal Antibody
别名
CSNBAD1; OPN2; opsd; Opsin 2 rod pigment; Opsin2; Retinitis pigmentosa 4 autosomal dominant; RHO; Rhodopsin; RP4;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P08100
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
Rhodopsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Rod shaped photoreceptor cells which mediate vision in dim light
细胞定位
Membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia
功能
Photoreceptor required for image-forming vision at low light intensity (PubMed:
8107847, PubMed:
7846071). Required for photoreceptor cell viability after birth (PubMed:
2215617, PubMed:
12566452). Light- induced isomerization of the chromophore 11-cis-retinal to all-trans- retinal triggers a conformational change that activates signaling via G-proteins (PubMed:
8107847, PubMed:
28524165, PubMed:
26200343, PubMed:
28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:
28524165, PubMed:
26200343).
