RM5113

TIMP1 (9Y15) Rabbit Monoclonal Antibody

EPO; EPA; TIMP1; CLGI;

Affinity-chromatography

常规抗体

TIMP1

CLGI, TIMP

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

7076

P01033

WB 1:100~1:500 IHC 1:50~1:200 ICC/IF 1:50~1:200

23kDa

Rabbit IgG

TIMP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Detected in rheumatoid synovial fluid (at protein level).

Secreted

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

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