产品名称
CD147 (11A16) Rabbit Monoclonal Antibody
别名
Basigin; 5F7; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; TCSF; CD147; BSG;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P35613
免疫原
A synthetic peptide of human CD147
稀释度
WB: 1:1000-1:5000 IHC: 1:50-1:200 ICC/IF: 1:20-1:50
注意事项
CD147 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
[Isoform 1]: Retina-specific (PubMed:25957687). Expressed in retinal cone photoreceptors (at protein level) (PubMed:25957687). [Isoform 3]: Highly expressed in the bone marrow, fetal liver, lung, testis and thymus.
细胞定位
Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. [Isoform 2]: Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Endosome Endoplasmic reticulum membrane; Single- pass type I membrane protein {ECO:0000250|UniProtKB:P26453} Basolateral cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453} [Isoform 4]: Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}
功能
[Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:
25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:
25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:
21620857).
