产品名称
CEA(CD66e) (7M6) Rabbit Monoclonal Antibody
别名
adhesion molecule 5; CD66e; Ceacam5; Meconium antigen 100;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P06731
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
CEA(CD66e) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
细胞定位
Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface Note=Localized to the apical glycocalyx surface
功能
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:
2803308, PubMed:
10910050, PubMed:
10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:
2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:
10910050).
