产品名称
TRF1 (8B4) Rabbit Monoclonal Antibody
别名
TERF1; PIN2; TRBF1; TRF1;
纯度
Affinity-chromatography
蛋白名称
PIN2, TRBF1, TRF, TRF1
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P54274
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200
注意事项
TRF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed and ubiquitous. Isoform Pin2 predominates
细胞定位
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle
功能
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
