产品名称
NUMB (16Y18) Rabbit Monoclonal Antibody
别名
c14_5527; h Numb; Numb; Numb homolog; S171;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P49757
免疫原
Recombinant protein of human NUMB
稀释度
WB: 1:1000 IHC: 1:200 FC: 1:100 IP: 1:20
注意事项
NUMB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner.
功能
Regulates clathrin-mediated receptor endocytosis (PubMed:
18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity).
