产品名称
SERCA2 (13M14) Rabbit Monoclonal Antibody
别名
SERCA2; Calcium pump 2; ATP2B;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P16615
免疫原
A synthetic peptide of human SERCA2 ATPase
稀释度
WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:50 FC: 1:20-1:100
注意事项
SERCA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart
细胞定位
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O55143}; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein
功能
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:
16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:
28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:
28890335).
