产品名称
ERCC1 (7J10) Rabbit Monoclonal Antibody
别名
COFS4; DNA excision repair protein ERCC-1; ERCC1; UV20; RAD10;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P07992
免疫原
A synthetic peptide of human ERCC1
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:100 ICC/IF: 1:20-1:100 FC: 1:50
注意事项
ERCC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
[Isoform 1]: Nucleus [Isoform 3]: Nucleus
功能
[Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
