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FOXA1 (13U2) Rabbit Monoclonal Antibody

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产品基本信息

产品货号
RM5063
产品名称
FOXA1 (13U2) Rabbit Monoclonal Antibody
别名
FOXA1; Forkhead box A1; Forkhead box protein A1; HNF-3-alpha; TCF3A; HNF3A; Transcription factor 3A;
纯度
Affinity-chromatography
类别
常规抗体
基因名称
FOXA1
蛋白名称
HNF3A, TCF3A
推荐应用
WB
反应种属
Human,Mouse,Rat
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Gene ID
3169
Human Swissprot No.
P55317
免疫原
Recombinant protein of human FOXA1
稀释度
WB: 1:1000-1:5000 IHC: 1:20 ICC/IF: 1:20 FC: 1:20
参考分子量
49kDa
预测分子量
49kDa
同种型
Rabbit IgG
注意事项
FOXA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}
功能
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
期货
现货

Western blot analysis of FOXA1 expression in HepG2 cell lysate.

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