RM5051

Ctip2 (2A18) Rabbit Monoclonal Antibody

ATL1 alpha; ATL1 beta; ATL1 gamma; ATL1 delta; Bcl11b; BCL11B/TRDC fusion; CTIP2; hRIT1 alpha; hRit1; Rit1;

Affinity-chromatography

常规抗体

BCL11B

CTIP2, RIT1

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

64919

Q9C0K0

A synthetic peptide of human Ctip2

WB: 1:2000-1:10000 FC: 1:20

120-130kDa

96kDa

Rabbit IgG

Ctip2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma

Nucleus.

Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).

现货