产品名称
DHX16 Rabbit Polyclonal Antibody
基因名称
DHX16 DBP2 DDX16 KIAA0577
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8449
Human Swissprot No.
O60231
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60231/entry
免疫原
Synthesized peptide derived from human DHX16 AA range: 216-266
特异性
This antibody detects endogenous levels of DHX16 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009],
组织表达
Expressed in the spleen, thyroid and testis. Also expressed in the brain and cerebellum.
细胞定位
Nucleus . Nucleus, nucleoplasm .
功能
function:Probable ATP-binding RNA helicase involved in pre-mRNA splicing.,similarity:Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
