产品名称
HMGCR (10J19) Rabbit Monoclonal Antibody
别名
3H3M; HMDH; HMG CoA reductase; HMG CoAR;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P04035
免疫原
A synthetic peptide of human HMGCR
注意事项
HMGCR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
[Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland. [Isoform 3]: Low abundance except in skin, esophagus, and uterine cervix.
细胞定位
Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}. Peroxisome membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}
功能
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:
2991281, PubMed:
21357570, PubMed:
6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:
11349148, PubMed:
18540668).
