RM5025

BMP11 (6S18) Rabbit Monoclonal Antibody

GDF11; BMP11; Bone morphogenetic protein 11; GDF-11; BMP-11;

Affinity-chromatography

常规抗体

GDF11

BMP11 {ECO:0000303|PubMed:10075854}

WB

Human,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

10220

O95390

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

45kDa

Rabbit IgG

BMP11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme

Secreted.

Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed:31215115). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).

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