产品名称
PLAT (12E12) Rabbit Monoclonal Antibody
别名
TPA; T-PA; TPA1; PLAT; Tissue plasminogen activator;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P00750
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
PLAT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk
细胞定位
Secreted, extracellular space.
功能
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity).
