产品名称
67kDa Laminin Receptor (10T12) Rabbit Monoclonal Antibody
别名
RPSA; 37LRP; 67LR; LAMR1; LAMBR; LamR; LRP/LR; RSSA;
纯度
Affinity-chromatography
基因名称
RPSA {ECO:0000255|HAMAP-Rule:MF_03016}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P08865
免疫原
A synthetic peptide of human 67kDa Laminin Receptor
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 FC: 1:20 IP: 1:20
注意事项
67kDa Laminin Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity) Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP- Rule:MF_03016}
功能
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.
