RM5015

Mitofusin1 (7N12) Rabbit Monoclonal Antibody

MFN1; Fzo homolog; Hfzo2; Mitofusin-1; Hfzo1; Mitofusin1;

Affinity-chromatography

常规抗体

MFN1

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

55669

Q8IWA4

WB 1:1000~1:5000 IP 1:20 FC 1:20

84kDa

Rabbit IgG

Mitofusin1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376) Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411).

Mitochondrion outer membrane; Multi-pass membrane protein

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).

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