产品名称
67kDa Laminin Receptor (10T12) Rabbit Monoclonal Antibody
别名
RPSA; 37LRP; 67LR; LAMR1; LAMBR; LamR; LRP/LR; RSSA;
纯度
Affinity-chromatography
基因名称
RPSA {ECO:0000255|HAMAP-Rule:MF_03016}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P08865
免疫原
A synthetic peptide of human 67kDa Laminin Receptor
注意事项
67kDa Laminin Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity) Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP- Rule:MF_03016}
功能
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.
