产品名称
Fas (6T3) Rabbit Monoclonal Antibody
别名
FAS; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P25445
免疫原
A synthetic peptide of human Fas
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 FC: 1:20
注意事项
Fas Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane raft [Isoform 3]: Secreted. [Isoform 5]: Secreted.
功能
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
