产品名称
PTP1B (13P19) Rabbit Monoclonal Antibody
别名
CPTP1; PTN1; PTP-1B; PTP-HA2; PTPN1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P18031
稀释度
WB 1:500~1:2000 IHC 1:50~1:100 ICC/IF 1:50~1:100 FC 1:20
注意事项
PTP1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in keratinocytes (at protein level).
细胞定位
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Note=Interacts with EPHA3 at the cell membrane
功能
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
