RM4992

Bmi1 (10S4) Rabbit Monoclonal Antibody

BMI1 ; Polycomb complex protein BMI 1; RING finger protein 51; RNF51; PCGF4;

Affinity-chromatography

常规抗体

BMI1

PCGF4, RNF51

WB

Human,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

100532731;648

P35226

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

37kDa

Rabbit IgG

Bmi1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus. Cytoplasm

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).

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