RM4982

IGF2 (9K5) Rabbit Monoclonal Antibody

C11orf43; IGF 2; IGF II; IGF2; INSIGF; Somatomedin A;

Affinity-chromatography

常规抗体

IGF2

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

3481

P01344

WB 1:500~1:2000 ICC/IF 1:50~1:100

20kDa

Rabbit IgG

IGF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.

Secreted.

The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).

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