产品名称
TRFM Rabbit Polyclonal Antibody
蛋白名称
Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P08582
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P08582/entry
Mouse Swissprot No.
Q9R0R1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R0R1
免疫原
Synthesized peptide derived from human protein . at AA range: 210-290
特异性
TRFM Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008],
组织表达
Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.
细胞定位
[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.
功能
function:Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.,similarity:Belongs to the transferrin family.,similarity:Contains 2 transferrin-like domains.,tissue specificity:Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
