RM4961

iNOS (12H16) Rabbit Monoclonal Antibody

HEP-NOS; Hepatocyte NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS2;

Affinity-chromatography

常规抗体

NOS2

NOS2A

WB

Human,Mouse

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

4843

P35228

WB 1:500~1:1000 ICC/IF 1:50~1:200 IP 1:50

131kDa

Rabbit IgG

iNOS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets

Cytoplasm, cytosol. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization.

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).

现货