RM4959

SUZ12 (19E19) Rabbit Monoclonal Antibody

CHET9; JJAZ1; KIAA0160; SUZ12;

Affinity-chromatography

常规抗体

SUZ12

CHET9, JJAZ1, KIAA0160

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

23512

Q15022

A synthetic peptide of human SUZ12

WB: 1:1000 ICC/IF: 1:20 FC: 1:200 IP: 1:20

83kDa

83kDa

Rabbit IgG

SUZ12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Overexpressed in breast and colon cancer.

Nucleus Note=Localizes to chromatin as part of the PRC2 complex

Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557).

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