产品名称
PD-L1 (CD274) (5R18) Rabbit Monoclonal Antibody
别名
B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; CD274;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9NZQ7
稀释度
WB 1:100~1:500 IHC 1:50~1:100
注意事项
PD-L1 (CD274) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
细胞定位
Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation. [Isoform 2]: Endomembrane system; Single-pass type I membrane protein
功能
Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:
11015443, PubMed:
28813417, PubMed:
28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:
11015443, PubMed:
28813417, PubMed:
28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:
10581077).
