RM4948

Integrin alpha 5 (10B18) Rabbit Monoclonal Antibody

Integrin alpha-5; VLA-5; CD49e; ITGA5; FNRA;

Affinity-chromatography

常规抗体

ITGA5

FNRA

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

3678

P08648

A synthetic peptide of human Integrin alpha 5

WB: 1:1000-1:5000 IHC: 1:200-1;500 ICC/IF: 1:50 FC: 1:20 IP: 1:20

150kDa

115kDa

Rabbit IgG

Integrin alpha 5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).

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