产品名称
CDC5 (16S9) Rabbit Monoclonal Antibody
别名
CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1; CDC5L;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q99459
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
CDC5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed in both fetal and adult tissues.
细胞定位
Nucleus. Nucleus speckle. Cytoplasm Note=May shuttle between cytoplasm and nucleus
功能
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:
11991638, PubMed:
20176811, PubMed:
28502770, PubMed:
28076346, PubMed:
29361316, PubMed:
29360106, PubMed:
29301961, PubMed:
30728453, PubMed:
30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:
20176811).
