产品名称
HDAC8 (4X4) Rabbit Monoclonal Antibody
别名
Histone deacetylase 8; HD8; HDAC8; HDACL1; CDA07; RPD 3; MRXS6;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9BY41
稀释度
WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:30 FC 1:30
注意事项
HDAC8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.
细胞定位
Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation
功能
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
