产品名称
14-3-3 Theta (12N1) Rabbit Monoclonal Antibody
别名
14-3-3 protein T cell; 14-3-3 protein tau; 14-3-3 protein theta; IC5; Protein HS1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P27348
免疫原
A synthetic peptide of human 14-3-3 Theta/Tau
稀释度
WB: 1:2000-1:10000 ICC/IF: 1:20 FC: 1:100-1:500
注意事项
14-3-3 Theta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement
细胞定位
Cytoplasm. Note=In neurons, axonally transported to the nerve terminals
功能
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
