产品名称
14-3-3 alpha + beta (10Z17) Rabbit Monoclonal Antibody
别名
14 3 3 protein beta/alpha; Brain protein 14 3 3 beta isoform; GW128; HS 1; KCIP-1; KCIP1; Protein 1054; Protein kinase C inhibitor protein 1; YWHAA; YWHAB;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P31946
免疫原
A synthetic peptide of human 14-3-3 alpha/beta
稀释度
WB: 1:1000 IHC: 1:200-1:1000 ICC:/IF 1:200
注意事项
14-3-3 alpha + beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
功能
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
