产品名称
PAX6 (14C4) Rabbit Monoclonal Antibody
别名
Paired box protein Pax-6; Aniridia type II protein; Oculorhombin; PAX6; AN2;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P26367
免疫原
Recombinant protein of human PAX6
稀释度
WB: 1:1000 IHC: 1:20-1:500 ICC/IF: 1:50
注意事项
PAX6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
[Isoform 1]: Expressed in lymphoblasts.
细胞定位
Nucleus {ECO:0000250|UniProtKB:P63015}. [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}
功能
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1- mediated gene expression (By similarity).
