产品名称
Stromal interaction molecule 1 (7O14) Rabbit Monoclonal Antibody
别名
GOK; SIM; STIM 1; Stim1 stromal interaction molecule 1; STIM1L; Stromal interaction molecule 1;
纯度
Affinity-chromatography
蛋白名称
GOK {ECO:0000303|PubMed:9377559}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q13586
免疫原
A synthetic peptide of human Stromal interaction molecule 1
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:50 IP: 1:20-1:50
注意事项
Stromal interaction molecule 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed in various human primary cells and tumor cell lines.
细胞定位
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single- pass type I membrane protein. Cytoplasm, cytoskeleton. Sarcoplasmic reticulum. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159) Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the cell membrane (PubMed:27185316). Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316).
功能
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:
15866891, PubMed:
16005298, PubMed:
16208375, PubMed:
16537481, PubMed:
16733527, PubMed:
16766533, PubMed:
16807233, PubMed:
18854159, PubMed:
19249086, PubMed:
22464749, PubMed:
24069340, PubMed:
24351972, PubMed:
24591628, PubMed:
26322679, PubMed:
25326555, PubMed:
28219928). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release- activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:
16208375, PubMed:
16537481). Involved in enamel formation (PubMed:
24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:
26322679).
