RM4854

HDAC10 (5B13) Rabbit Monoclonal Antibody

HD10; HDAC 10; Hdac10; Histone deacetylase 10; MGC149722;

Affinity-chromatography

常规抗体

HDAC10

WB

Human,Mouse

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

83933

Q969S8

WB 1:1000~1:2000 ICC/IF 1:50~1:200 IP 1:50

71kDa

Rabbit IgG

HDAC10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed with high levels in liver and kidney.

Cytoplasm. Nucleus Note=Excluded from nucleoli.

Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome- lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039).

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