RM4836

STAT2 (16M4) Rabbit Monoclonal Antibody

Homo sapiens interferon alpha induced transcriptional activator; ISGF 3; P113; signal transducer and activator of transcription 2 113kD; STAT113; Stat2;

Affinity-chromatography

常规抗体

STAT2

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

6773

P52630

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

98kDa

Rabbit IgG

STAT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm. Nucleus Note=Translocated into the nucleus upon activation by IFN-alpha/beta

Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121, PubMed:23391734, PubMed:9020188).

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