RM4833

MEK2 (2W8) Rabbit Monoclonal Antibody

Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2; MAP2K2; MEK-2; MKK2; PRKMK2;

Affinity-chromatography

常规抗体

MAP2K2

MEK2, MKK2, PRKMK2

WB

Human,Mouse

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

5605

P36507

A synthetic peptide of human MEK2

WB: 1:2000 IHC: 1:20 ICC/IF: 1:20 FC: 1:20 IP: 1:20

43kDa

43kDa

Rabbit IgG

MEK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane localization is probably regulated by its interaction with KSR1.

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).

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