产品名称
14-3-3 sigma (5P11) Rabbit Monoclonal Antibody
别名
14 3 3 protein; Epithelial cell marker protein 1; HME 1; Mkrn3; Mme1; SFN protein; Stratifin; YWHAS;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P31947
稀释度
WB 1:1000~1:2000 IHC 1:50~1:200
注意事项
14-3-3 sigma Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Present mainly in tissues enriched in stratified squamous keratinizing epithelium
细胞定位
Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway
功能
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
