产品名称
MALD2 Rabbit Polyclonal Antibody
蛋白名称
MARVEL domain-containing protein 2 (Tricellulin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N4S9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N4S9/entry
Mouse Swissprot No.
Q3UZP0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UZP0
免疫原
Synthesized peptide derived from human protein . at AA range: 170-250
特异性
MALD2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
组织表达
Brain,Epithelium,Lung,Trachea,
细胞定位
Cell membrane ; Multi-pass membrane protein . Cell junction, tight junction . Located at tricellular contacts. .
功能
disease:Defects in MARVELD2 are the cause of non-syndromic sensorineural deafness autosomal recessive type 49 (DFNB49) [MIM:610153]. DFNB49 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 MARVEL domain.,subcellular location:Found at tricellular contacts.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
