产品名称
IRF2 (19Z15) Rabbit Monoclonal Antibody
别名
Interferon regulatory factor 2; IRF 2;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P14316
稀释度
WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
IRF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
功能
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
