产品名称
pro Caspase 7 (10O2) Rabbit Monoclonal Antibody
别名
apoptosis-related cysteine peptidase; Apoptotic protease Mch-3; CASP-7; Caspase-7 subunit p11; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3;
纯度
Affinity-chromatography
蛋白名称
MCH3 {ECO:0000303|PubMed:8521391}
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P55210
稀释度
WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
pro Caspase 7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain
功能
Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:
8521391, PubMed:
8576161, PubMed:
8567622, PubMed:
9070923, PubMed:
11701129). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:
8521391, PubMed:
8576161, PubMed:
8567622, PubMed:
9070923). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death (PubMed:
8521391, PubMed:
8576161, PubMed:
8567622, PubMed:
9070923). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity).
