RM4798

Cyclin D3 (13I18) Rabbit Monoclonal Antibody

CCND 3; Ccnd3; CyclinD3; D3 type cyclin; G1 S specific cyclin D3;

Affinity-chromatography

常规抗体

CCND3 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1585}

WB

Human,Mouse

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

896

P30281

WB 1:1000~1:2000 ICC/IF 1:50~1:200 FC 1:30

33kDa

Rabbit IgG

Cyclin D3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus. Cytoplasm

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D- CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120).

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