产品名称
SOX10 (14Q3) Rabbit Monoclonal Antibody
别名
SOX10; DOM; Transcription factor SOX-10; WS4; PCWH; WS2E; SRY-related HMG-box gene 10; WS4C;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P56693
免疫原
A synthetic peptide of human SOX10
稀释度
WB: 1:2000 ICC/IF: 1:50 FC: 1:20
注意事项
SOX10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in fetal brain and in adult brain, heart, small intestine and colon
细胞定位
Cytoplasm. Nucleus. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q04888}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q04888}; Cytoplasmic side {ECO:0000250|UniProtKB:Q04888}
功能
Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:
21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity).
