产品名称
SOX11 (12Z19) Rabbit Monoclonal Antibody
别名
MRD27; SOX11; SRY (sex determining region Y) box 11; SRY related HMG box gene 11 ; SRY-box 11; Transcription factor SOX-11;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P35716
稀释度
WB 1:1000~1:2000 ICC/IF 1:50~1:200 IP 1:50
注意事项
SOX11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed primarily in the brain and heart, with low expression in the kidney, pancreas and muscle
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:24886874}
功能
Transcription factor that acts as a transcriptional activator (PubMed:
24886874). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).
