产品名称
LRP12 Rabbit Polyclonal Antibody
蛋白名称
Low-density lipoprotein receptor-related protein 12 (LRP-12) (Suppressor of tumorigenicity 7 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y561
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y561/entry
Mouse Swissprot No.
Q8BUJ9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BUJ9
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
LRP12 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],
组织表达
Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
细胞定位
Membrane ; Single-pass type I membrane protein . Membrane, coated pit .
功能
function:Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.,similarity:Belongs to the LDLR family.,similarity:Contains 2 CUB domains.,similarity:Contains 5 LDL-receptor class A domains.,subunit:May interact with GNB2L1, MADHIP and ITGB1BP3.,tissue specificity:Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
