产品名称
ACSL5 Rabbit Polyclonal Antibody
基因名称
ACSL5 ACS5 FACL5 UNQ633/PRO1250
蛋白名称
Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9ULC5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ULC5/entry
Mouse Swissprot No.
Q8JZR0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8JZR0
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O88813
免疫原
Synthesized peptide derived from human protein . at AA range: 460-540
特异性
ACSL5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Mitochondrion . Endoplasmic reticulum . Mitochondrion outer membrane ; Single-pass type III membrane protein . Endoplasmic reticulum membrane ; Single-pass type III membrane protein . Cell membrane .
信号通路
Fatty acid metabolism;PPAR;Adipocytokine;
功能
catalytic activity:ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.,cofactor:Magnesium.,function:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
